Surface immobilization of galactose onto aliphatic biodegradable polymers for hepatocyte culture.

@article{Yoon2002SurfaceIO,
  title={Surface immobilization of galactose onto aliphatic biodegradable polymers for hepatocyte culture.},
  author={Jun Jin Yoon and Yoon Sung Nam and Jung Kim and Tae Gwan Park},
  journal={Biotechnology and bioengineering},
  year={2002},
  volume={78 1},
  pages={1-10}
}
A novel surface modification method of biodegradable polymers was investigated for inducing the attachment of specific cells onto the polymer surface via ligand-receptor interactions. Galactose, a targeting ligand specific to asialoglycoprotein receptors present on cell membrane of hepatocytes, was introduced on the surface of poly(D,L-lactic-co-glycolic acid) (PLGA) films. A terminal end group of carboxylic acid in PLGA was activated by dicyclohexylcarbodiimide and N-hydroxysuccinimide for the… CONTINUE READING