Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy.

@article{Tian2018SurfaceFE,
  title={Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy.},
  author={Tian Tian and Hui-xin Zhang and Chunpeng He and S. Fan and Yanliang Zhu and Cui Qi and Ning-Ping Huang and Zhong-Dang Xiao and Zu-Hong Lu and B. Tannous and Jun Gao},
  journal={Biomaterials},
  year={2018},
  volume={150},
  pages={
          137-149
        }
}
The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery efficiency, and ability to cross the blood-brain barrier (BBB). However, exosome insufficient targeting capability limits their clinical applications. In this study, the c(RGDyK) peptide has been… Expand
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