Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles.

@article{Cho2014SurfaceFA,
  title={Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles.},
  author={Wan-Seob Cho and Frank Thielbeer and R. Michael Duffin and Emma Matilda Johansson and Ian L Megson and W. MacNee and Mark Bradley and Ken Donaldson},
  journal={Nanotoxicology},
  year={2014},
  volume={8 2},
  pages={
          202-11
        }
}
Nano materials are commonly functionalized to boost their physicochemical properties. However, there is little known about the impact of these modifications on cellular systems. Herein, we synthesized eight types of polymeric nanoparticles (NPs) bearing different functional groups, and investigated their effects on interactions with cellular membranes. As models for particle membrane interactions, hemolysis assays using human red blood cells and culture with A549 cells were utilized. Under… CONTINUE READING
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Effects of p

  • Y Hu, L Yin, C Tang, C Yin
  • 2010

Role of surface charge and oxidative stress

  • rcelis ATM, H Zuilhof, Rietjens IMCM, GM Alink
  • 2010

Efficacy of simple short-term in vitro assays

  • W Macnee, V Stone, K Donaldson
  • 2009

The influence of protein adsorption on nanoparticle association with culture

  • G ter, JL McGrath
  • 2009

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