Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

@article{Shin2006SurfaceEO,
  title={Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination},
  author={Jeoung-Sook Shin and Melanie W. Ebersold and Marc Pypaert and L{\'e}lia Delamarre and Adam Hartley and Ira Mellman},
  journal={Nature},
  year={2006},
  volume={444},
  pages={115-118}
}
Dendritic cells have a unique function in the immune response owing to their ability to stimulate immunologically naive T lymphocytes. In response to microbial and inflammatory stimuli, dendritic cells enhance their capacity for antigen presentation by a process of terminal differentiation, termed maturation. The conversion of immature to mature dendritic cells is accompanied by a marked cellular reorganization, including the redistribution of major histocompatibility complex class II molecules… CONTINUE READING
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