Surface expression of CD39 identifies an enriched Treg-cell subset in the rheumatic joint, which does not suppress IL-17A secretion.

@article{Herrath2014SurfaceEO,
  title={Surface expression of CD39 identifies an enriched Treg-cell subset in the rheumatic joint, which does not suppress IL-17A secretion.},
  author={Jessica Herrath and Karine Chemin and Inka Albrecht and Anca Irinel Catrina and Vivianne Malmstr{\"o}m},
  journal={European journal of immunology},
  year={2014},
  volume={44 10},
  pages={2979-89}
}
Treg cells are important for the maintenance of self-tolerance and are implicated in autoimmunity. Despite enrichment of Treg cells in joints of rheumatoid arthritis (RA) patients, local inflammation persists. As expression of the ATP-hydrolyzing enzymes CD39 and CD73 and the resulting anti-inflammatory adenosine production have been implicated as an important mechanism of suppression, we characterized FOXP3(+) Treg cells in blood and synovial fluid samples of RA patients in the context of CD39… CONTINUE READING