Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues.

Abstract

There is a medical need for new insulin analogues. Yet, molecular alterations to the insulin molecule can theoretically result in analogues with carcinogenic effects. Preclinical carcinogenicity risk assessment for insulin analogues rests to a large extent on mitogenicity assays in cell lines. We therefore optimized mitogenicity assay conditions for a panel… (More)
DOI: 10.1002/jat.3082

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Cite this paper

@article{Lundby2015SurfaceexpressedIR, title={Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues.}, author={Anders Lundby and Pernille Bolvig and Anne Charlotte Hegelund and Bo Falck Hansen and Jesper Worm and Anne L{\"{u}tzen and Nils Billestrup and Christine Bonnesen and Martin B. Oleksiewicz}, journal={Journal of applied toxicology : JAT}, year={2015}, volume={35 7}, pages={842-50} }