Surface-enhanced nucleation of insulin amyloid fibrillation.

@article{Nayak2008SurfaceenhancedNO,
  title={Surface-enhanced nucleation of insulin amyloid fibrillation.},
  author={Arpan Nayak and Amit K. Dutta and Georges Belfort},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 2},
  pages={
          303-7
        }
}
Proteins can interact with biological surfaces such as cell membrane, chaperones, cornea, bone, arteries, veins, and heart cavities of the cardiovascular system and also with non-biological surfaces including dialysis membranes and tubing, catheters, invasive surgical instruments, needles, and artificial implants. Fibrillation of amyloid proteins is implicated in many human diseases, including Alzheimer's, Parkinson's, and type II diabetes. Here, we show that heterogeneous surfaces accelerate… CONTINUE READING

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