Surface engineered excipients: II. Simultaneous milling and dry coating for preparation of fine‐grade microcrystalline cellulose with enhanced properties

@article{Chen2018SurfaceEE,
  title={Surface engineered excipients: II. Simultaneous milling and dry coating for preparation of fine‐grade microcrystalline cellulose with enhanced properties},
  author={Liang Chen and Xiaoyi Ding and Zizhou He and Siqi Fan and Kuriakose T. Kunnath and Kai Zheng and Rajesh N. Dav{\'e}},
  journal={International Journal of Pharmaceutics},
  year={2018},
  volume={546},
  pages={125–136}
}

Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing suitability of different dry coating processes.

Decoding Fine API Agglomeration as a Key Indicator of Powder Flowability and Dissolution: Impact of Particle Engineering.

PURPOSE Fine API agglomeration and its mitigation via particle engineering, i.e., dry coating, remains underexplored. The purpose was to investigate agglomeration before and after dry coating of fine

Co-processed tablet excipient composition, its preparation and use: US10071059 B2: patent spotlight.

Co-processing involves the incorporation of one excipients into the particle structure of other excipients to overcome the deficiencies of each excipients. The current patent describes the

Improving Feedability of Highly Adhesive Active Pharmaceutical Ingredients by Silication

Purpose Loss-in-weight feeders play a vital role in assuring blend and content uniformity as well as lot-to-lot powder traceability in continuous manufacturing. Irregular flow from the feeders

Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets.

Surface Modifiers on Composite Particles for Direct Compaction

Direct compaction (DC) is considered to be the most effective method of tablet production. However, only a small number of the active pharmaceutical ingredients (APIs) can be successfully

References

SHOWING 1-10 OF 69 REFERENCES

Profoundly improving flow properties of a cohesive cellulose powder by surface coating with nano-silica through comilling.

It is shown that powder flow can be substantially improved by reducing the cohesion of powders by coating them with nanosized guest particles, and that comilling is an efficient process for nanocoating.

Controlled release from drug microparticles via solventless dry-polymer coating.

The main hypothesis is that such process having highly controllable processing intensity and time may be effective for coating particularly fine particles, 100 μm and smaller via exploiting particle interactions between polymers and substrates in the dry state, while avoiding breakage yet achieving conformal coating.

Passivation of high-surface-energy sites of milled ibuprofen crystals via dry coating for reduced cohesion and improved flowability.

Overall, dry coating leads to decreased cohesion and improved flowability because of reduced LW dispersive component of surface energy and creating nanoscale surface roughness.
...