Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis.

@article{Donat2012SurfaceDO,
  title={Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis.},
  author={Stefanie Donat and Mike Hasenberg and T. Schaefer and Knut Ohlsen and Matthias Gunzer and Hermann Einsele and Juergen Loeffler and Andreas Beilhack and Sven Krappmann},
  journal={Virulence},
  year={2012},
  volume={3 1},
  pages={51-61}
}
Non-invasive imaging techniques in microbial disease models have delivered valuable insights in the intimate pathogen-host interplay during infection. Here we describe evaluation and validation of a transgenic bioluminescence reporter strain of the human-pathogenic mold Aspergillus fumigatus, one of the main fungal pathogens affecting immunocompromised individuals. Expression and surface display of the Gaussia princeps luciferase allowed sensitive and rapid detection of luminescence emitted… CONTINUE READING

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Highly Influential
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