Surface-dependent quartz uptake by macrophages: potential role in pulmonary inflammation and lung clearance.

@article{Albrecht2007SurfacedependentQU,
  title={Surface-dependent quartz uptake by macrophages: potential role in pulmonary inflammation and lung clearance.},
  author={Catrin Albrecht and Doris H{\"o}hr and Petra Haberzettl and Andrea Becker and Paul J. A. Borm and Roel P F Schins},
  journal={Inhalation toxicology},
  year={2007},
  volume={19 Suppl 1},
  pages={39-48}
}
Inhalation of quartz particles is associated with a variety of adverse lung effects. Since particle surface is considered to be crucial for particle pathogenicity, we investigated the influence of quartz surface properties on lung burden, inflammation (bronchoalveolar lavage cells), and cytotoxicity (protein, lactate dehydrogenase, beta-glucuronidase) 90 days after a single intratracheal instillation of 2 mg DQ12 into rats. The role of particle surface characteristics was investigated by… CONTINUE READING

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