Surface-dependent conformations of human plasma fibronectin adsorbed to silica, mica, and hydrophobic surfaces, studied with use of Atomic Force Microscopy.

@article{Bergkvist2003SurfacedependentCO,
  title={Surface-dependent conformations of human plasma fibronectin adsorbed to silica, mica, and hydrophobic surfaces, studied with use of Atomic Force Microscopy.},
  author={Magnus Bergkvist and Jan Carlsson and Sven Oscarsson},
  journal={Journal of biomedical materials research. Part A},
  year={2003},
  volume={64 2},
  pages={349-56}
}
Human plasma fibronectin (Fn) is a large flexible protein stabilized by intermolecular ionic interactions forming a compact structure. On altering solution conditions, the structure can revert to a more expanded state, thereby exposing previously hidden domains (e.g., cell-binding sites). Electron microscopy images of Fn air-sprayed onto mica surfaces show elongated protein structures, indicating a surface-induced structural change. This makes it interesting to investigate the influence of… CONTINUE READING

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