Surface co-expression of Vibrio cholerae and Salmonella typhi O-antigens on Ty21a clone EX210.

@article{Attridge1990SurfaceCO,
  title={Surface co-expression of Vibrio cholerae and Salmonella typhi O-antigens on Ty21a clone EX210.},
  author={Stephen R. Attridge and Dean Daniels and Judy K. Morona and Renato Morona},
  journal={Microbial pathogenesis},
  year={1990},
  volume={8 3},
  pages={177-88}
}
In an attempt to construct a bivalent, live, oral cholera-typhoid vaccine, genes specifying the biosynthesis of Vibrio cholerae O-antigen have been transferred into a modified version of the attenuated, oral typhoid vaccine strain Salmonella typhi Ty21a. The present report investigates the production of V. cholerae and S. typhi O-antigens by one such clone, EX210. When cultured without galactose supplementation EX210 produces surface O-antigen of V. cholerae type, as detected by… CONTINUE READING

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