Surface charge-modification prevents sequestration and enhances tumor-cell specificity of a recombinant granzyme B-TGFα fusion protein.

@article{Jabulowsky2012SurfaceCP,
  title={Surface charge-modification prevents sequestration and enhances tumor-cell specificity of a recombinant granzyme B-TGFα fusion protein.},
  author={Robert A. Jabulowsky and Pranav Oberoi and Hayat B{\"a}hr-Mahmud and Benjamin D{\"a}lken and Winfried S. Wels},
  journal={Bioconjugate chemistry},
  year={2012},
  volume={23 8},
  pages={1567-76}
}
The serine protease granzyme B (GrB) plays an important role in the immune defense mediated by cytotoxic lymphocytes. Recombinant derivatives of this pro-apoptotic protein fused to tumor-targeting ligands hold promise for cancer therapy, but their applicability may be limited by promiscuous binding to nontarget tissues via electrostatic interactions. Here, we investigated cell binding and specific cytotoxicity of chimeric molecules consisting of wild-type or surface-charge-modified human GrB… CONTINUE READING
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