Surface charge distribution is a determinant of antigen deposition in the renal glomerulus: studies employing 'charge-hybrid' molecules.

@article{Batsford1991SurfaceCD,
  title={Surface charge distribution is a determinant of antigen deposition in the renal glomerulus: studies employing 'charge-hybrid' molecules.},
  author={S. R. Batsford and Michael J{\"o}rg Mihatsch and M Rawiel and T M Schmiedeke and Arnold Vogt},
  journal={Clinical and experimental immunology},
  year={1991},
  volume={86 3},
  pages={471-7}
}
The deposition of antigens and immune complexes (IC) in the renal glomerulus is charge-dependent. The demonstration that molecules of net anionic charge, but with discrete positively charged regions, exhibit affinity for the glomerular basement membrane (GBM) extends this concept. Charge hybrid (polar) molecules were constructed by covalently coupling small polycations (lysozyme or linear poly-L-lysine chains with a mean of 17 and 20 residues) to larger polyanions (ovalbumin or human serum… CONTINUE READING