Surface-catalyzed amyloid fibril formation.

@article{Zhu2002SurfacecatalyzedAF,
  title={Surface-catalyzed amyloid fibril formation.},
  author={Min Zhu and Pierre O Souillac and Cristian Ionescu-Zanetti and S. Andrew Carter and Anthony L. Fink},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 52},
  pages={50914-22}
}
Light chain (or AL) amyloidosis is characterized by the pathological deposition of insoluble fibrils of immunoglobulin light chain fragments in various tissues, walls of blood vessels, and basement membranes. In the present investigation, the in vitro assembly of a recombinant amyloidogenic light chain variable domain, SMA, on various surfaces was monitored using atomic force microscopy. SMA formed fibrils on native mica at pH 5.0, conditions under which predominantly amorphous aggregates form… CONTINUE READING

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Colloids Surf. 22, 285–300 Surface-catalyzed Amyloid Fibril Formation

  • C. J. Van Oss, A. Docoslis, R. F. Giese, Jr.
  • 2001

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