Surface binding and uptake of cadmium (Cd2+) by LLC-PK1 cells on permeable membrane supports

@article{Prozialeck1993SurfaceBA,
  title={Surface binding and uptake of cadmium (Cd2+) by LLC-PK1 cells on permeable membrane supports},
  author={Walter C. Prozialeck and Peter C. Lamar},
  journal={Archives of Toxicology},
  year={1993},
  volume={67},
  pages={113-119}
}
Recent studies have shown that Cd2+ has relatively specific damaging effects on cell-cell junctions in the renal epithelial cell line, LLC-PK1. The objective of the present studies was to examine the surface binding and uptake of Cd2+ by LLC-PK1 cells in relation to the disruption of cell-cell junctions. LLC-PK1 cells on Falcon Cell Culture Inserts were exposed to CdCl2 containing trace amounts of109Cd2+ from either the apical or the basolateral compartments, and the accumulation of109Cd2+ was… CONTINUE READING