Surface binding and intracellular uptake of gentamicin in the cultured kidney epithelial cell line (LLC-PK1).

Abstract

Aminoglycoside antibiotics such as gentamicin are taken up by renal proximal tubular cells, yet little is known regarding the biochemical characteristics of the transport process at the cellular level. In this report, cellular handling of gentamicin was studied in the cultured kidney epithelial cell line LLC-PK1. After 2 days of incubation of the cells with… (More)

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