Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide.

@article{Ambroggio2005SurfaceBA,
  title={Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide.},
  author={Ernesto E Ambroggio and Dennis Heejong Kim and Frances Separovic and Colin James Barrow and Kevin Jeffrey Barnham and Luis A. Bagatolli and Gerardo Daniel Fidelio},
  journal={Biophysical journal},
  year={2005},
  volume={88 4},
  pages={2706-13}
}
Amyloid aggregates, found in patients that suffer from Alzheimer's disease, are composed of fibril-forming peptides in a beta-sheet conformation. One of the most abundant components in amyloid aggregates is the beta-amyloid peptide 1-42 (Abeta 1-42). Membrane alterations may proceed to cell death by either an oxidative stress mechanism, caused by the peptide and synergized by transition metal ions, or through formation of ion channels by peptide interfacial self-aggregation. Here we demonstrate… CONTINUE READING

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