Surface-assisted laser desorption/ionization mass spectrometry

  title={Surface-assisted laser desorption/ionization mass spectrometry},
  author={Andrew Martin Dattelbaum and Srinivas Iyer},
  journal={Expert Review of Proteomics},
  pages={153 - 161}
Laser desorption/ionization mass spectrometry (MS) is rapidly growing in popularity as an analytical characterization method in several fields. The technique shot to prominence using matrix-assisted desorption/ionization for large biomolecules (>700 Da), such as proteins, peptides and nucleic acids. However, because the matrix, which consists of small organic molecules, is also ionized, the technique is of limited use in the low-molecular-mass range (<700 Da). Recent advances in surface science… 

Desorption and ionization mechanisms and signal enhancement in surface assisted laser desorption ionization mass spectrometry (SALDI-MS)

Abstract Surface assisted laser desorption ionization mass spectrometry (SALDI-MS) has been recognized as one of the prominent techniques in mass analysis of small molecules as well as large

Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review

The implementation of SALDI-MS imaging (SALDI- MSI), which is the focus of this review, opens up new opportunities and some perspectives of this technique, which has a bright future, are proposed.

Nanoparticle assisted laser desorption/ionization mass spectrometry for small molecule analytes

This review covers the progress made in laser-based mass spectrometry in combination with the use of metallic NPs, NPs consisting of oxides and chalcogenides, silicon-based NPS, carbon-based nanomaterials, quantum dots, and metal-organic frameworks.

Recent advances in SALDI-MS techniques and their chemical and bioanalytical applications

The physical and chemical processes involved in SALDI are described and how the unique physical and electronic properties of nanostructured surfaces allow them to substitute for the matrix in energy transfer processes are explained.

Revisiting the quantitative features of surface-assisted laser desorption/ionization mass spectrometric analysis

In this study, the coffee-ring effect is discussed using nanoparticles and nanostructured substrates as SALDI-assisting materials to show how this effect influences SAL DI-MS analysis results.

Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays.

Porosity, length and diameter are fabrication parameters that are explored here in order to optimize analytical performance and the quantitative analysis of methadone in MilliQ water down to 32 ng mL(-1) is demonstrated.

Ionic matrix for matrix-enhanced surface-assisted laser desorption ionization mass spectrometry imaging (ME-SALDI-MSI)

  • Qiang LiuLin He
  • Chemistry
    Journal of the American Society for Mass Spectrometry
  • 2009

Matrix-free laser desorption/ionisation mass spectrometry on rough or porous semiconductor substrates: theory and applications

This project aimed to develop a high throughput, laser based, matrix-free, mass spectrometric technique using nanoporous and nanostructured semiconductor substrates for rapid, sensitive, high

Minimization of Fragmentation and Aggregation by Laser Desorption Laser Ionization Mass Spectrometry

This work finds significant fragmentation and aggregation in SALDI, such that individual fragment and aggregate peaks are typically more intense than the parent peak, and highlights some advantages of L2MS for analysis of complex mixtures such as asphaltenes.



Mesoporous Silica for Desorption-Ionization Mass Spectrometry

Here we demonstrate the use of mesoporous silica thin films for matrix free laser desorption/ionization mass spectrometry (MS). In spite of the growing acceptance of matrix-assisted laser

Small molecule matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a polymer matrix.

This method addresses the problem of matrix interference which limits the usefulness of MALDI-TOF for small molecule analysis by employing a light-absorbing electrically conductive polymer as a matrix to determine the molecular mass of small organic molecules using matrix-assisted laser desorption/ionization time-of-flight (MALDI-ToF) mass spectrometry.

Carbon nanotubes as assisted matrix for laser desorption/ionization time-of-flight mass spectrometry.

It has been found that carbon nanotubes can transfer energy to the analyte under laser irradiation, which makes analytes well desorbed/ionized, and the interference of intrinsic matrix ions can be eliminated.

Desorption–ionization mass spectrometry on porous silicon

A matrix-free strategy forbiomolecular mass spectrometry based on pulsed-laser desorption–ionization from a porous silicon surface that offers good sensitivity as well as compatibility with silicon-based microfluidics and microchip technologies.

Polymer-assisted laser desorption/ionization analysis of small molecular weight compounds.

The use of non-polar, small polymers as matrices for the analysis of low molecular weight compounds in polymer-assisted laser desorption/ionization mass spectrometry (PALDI-MS) is demonstrated, and some aspects of the ionization/desorption process leading to radical cations are studied.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an inorganic particle matrix for small molecule analysis

TiO2 powder seemed to be a broad potential matrix for low molecular mass polar or non-polar analytes, and can be readily applied to obtain the low background noise MALDI-TOF mass spectra of small-sized compounds.

Desorption/ionization mass spectrometry on nanocrystalline titania sol-gel-deposited films.

This paper describes a matrix-free method for performing desorption/ionization directly from mesoporous nanocrystalline titania sol-gel thin films, which have good absorption capacity in the

Matrix-assisted and polymer-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of low molecular weight polystyrenes and polyethylene glycols.

Comparison of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) data for two very low molecular weight polymers with data obtained from size-exclusion chromatography (SEC) revealed a systematic difference regarding mean molecular weight and dispersity.

Graphite surface-assisted laser desorption/ionization time-of-flight mass spectrometry of peptides and proteins from liquid solutions.

Laser desorption time-of-flight mass spectra of peptides and proteins, as well as of lower molecular weight analytes, have been obtained by using a pulsed nitrogen UV laser (337 nm) to irradiate