Surface area of the digestive tract – revisited

  title={Surface area of the digestive tract – revisited},
  author={Herbert F. Helander and Lars F{\"a}ndriks},
  journal={Scandinavian Journal of Gastroenterology},
  pages={681 - 689}
BACKGROUND According to textbooks, the human gut mucosa measures 260-300 m(2), that is, in the order of a tennis court. [] Key MethodRESULTS Literature review of intubation or radiological methods indicates an oroanal length of ∼5 m, two-third of which refers to the small intestine. However, there is a considerable variation between individuals. The inner diameter of the small intestine averages 2.5 cm and that of the large intestine averages 4.8 cm. The mucosa of the small intestine is enlarged ∼1.6 times…
Recent Studies on Digestive System Anatomy
The mean total mucosal surface of the human digestive tract averages ~32 m2, of which about 2 m2 corresponds to that of the large intestine [1]. The latter is built of a single layer of epithelial
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The authors discovered that the lung microbiome in patients with BADE is distinct from that of matched BADEfree subjects, more closely resembling microbial communities detected in on-site metalworking fluid.
Development and Anatomy of the Enteroendocrine System in Humans.
The anatomical characteristics, development, differentiation and maturation of EECs are described, and their important biological potential illustrated as part of the gut interacting sensory system.
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The results suggest that dense bacterial colonization of jejunum mucosa is possible in the presence of multiple perturbations and that villus loss may be one possible consequence to such colonization.
Topography and microstructural organization of lymphoid formations associated with pig intestinal mucosa
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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
There was no additional increase in mannitol permeability induced by luminal ethanol or SDS in the chemotherapy-treated rats compared to controls, which may be related to the relatively high basal permeability ofMannitol compared to other common low-permeability probes.
Ultrastructural intestinal mucosa change after prolonged inhibition of gastric acid secretion by omeprazole in male rats
Omeprazole is a potent inhibitor of gastric acid secretion. It was reported that omeprazole induced dramatic gastric mucosa morphologic changes from the resting state to the stimulated state.


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A new method is described to measure the intestines of animals ranging in size from the harvest mouse to the horse, which may be applicable to other hollow or tube-like organs, and has two levels: obtaining the basal surface area of the entire intestine and accounting for any increase in the mucosal surface area that is due to microscopically visible folds, villi, or other such structures.
The oral mucosal surface and blood vessels
The total size of the oral mucosa was determined to show that the dorsal side of the tongue comprises a large proportion of the total oral mucosal surface and plays an important role in the oral resorption of drugs.
[Quantification of the three-dimensional structure of jejunal mucosa in healthy subjects and patients with coeliac disease (author's transl)].
Mucosal transformation in coeliac disease was associated with a decrease in villi and crypts per mm2 intestine as well as in mucosal surface and an increase in crypt depth and number of mitotic figures per crypt.
Parenteral versus enteral nutrition: morphological changes in human adult intestinal mucosa.
Investigation of the effect of parenteral nutrition on the intestinal mucosa of human adults found that the thickness of the jejunal mucosa decreased already in enterally nourished patients with chronic pancreatitis, but was enhanced after total parenTERal nutrition.
Targeting in the gastrointestinal tract: new approaches.
  • W. Ritschel
  • Medicine
    Methods and findings in experimental and clinical pharmacology
  • 1991
Targeting utilizes the anatomic, histologic, physiologic and biochemical features of various segments within the alimentary canal, paired with the design of special drug delivery systems or devices, and the use of special vehicle substances, such as polymers, bioadhesives, sorption promoters, or chemical modification of the active moiety.
Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man
The results of this study are important for the appropriate dose translation of candidate therapeutic compounds in drug development from mouse to humans.
Analysis of length and surface area of each segment of the large intestine according to age, sex and physique
Length, diameter and surface area of each of 6 segments of the large intestine were determined and calculated in 920 Japanese patients who underwent barium enema, with various sex differences in size.
The present paper is a report of a quantitative study of the growth in number of the gastric crypts and glands in later fetal life, infancy, childhood and adolescence, and to this have been added data on the number of these structures in maturity.
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
  • T. Kararli
  • Biology
    Biopharmaceutics & drug disposition
  • 1995
In addition to metabolic differences, the anatomical, physiological, and biochemical differences in the gastrointestinal (G.I.) tract of the human and common laboratory animals can cause significant