Surface area of the digestive tract – revisited

@article{Helander2014SurfaceAO,
  title={Surface area of the digestive tract – revisited},
  author={Herbert F. Helander and Lars F{\"a}ndriks},
  journal={Scandinavian Journal of Gastroenterology},
  year={2014},
  volume={49},
  pages={681 - 689}
}
BACKGROUND According to textbooks, the human gut mucosa measures 260-300 m(2), that is, in the order of a tennis court. [] Key MethodRESULTS Literature review of intubation or radiological methods indicates an oroanal length of ∼5 m, two-third of which refers to the small intestine. However, there is a considerable variation between individuals. The inner diameter of the small intestine averages 2.5 cm and that of the large intestine averages 4.8 cm. The mucosa of the small intestine is enlarged ∼1.6 times…
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References

SHOWING 1-10 OF 42 REFERENCES
Intestinal Absorptive Surface in Mammals of Different Sizes
TLDR
A new method is described to measure the intestines of animals ranging in size from the harvest mouse to the horse, which may be applicable to other hollow or tube-like organs, and has two levels: obtaining the basal surface area of the entire intestine and accounting for any increase in the mucosal surface area that is due to microscopically visible folds, villi, or other such structures.
The oral mucosal surface and blood vessels
TLDR
The total size of the oral mucosa was determined to show that the dorsal side of the tongue comprises a large proportion of the total oral mucosal surface and plays an important role in the oral resorption of drugs.
[Quantification of the three-dimensional structure of jejunal mucosa in healthy subjects and patients with coeliac disease (author's transl)].
TLDR
Mucosal transformation in coeliac disease was associated with a decrease in villi and crypts per mm2 intestine as well as in mucosal surface and an increase in crypt depth and number of mitotic figures per crypt.
Parenteral versus enteral nutrition: morphological changes in human adult intestinal mucosa.
TLDR
Investigation of the effect of parenteral nutrition on the intestinal mucosa of human adults found that the thickness of the jejunal mucosa decreased already in enterally nourished patients with chronic pancreatitis, but was enhanced after total parenTERal nutrition.
Targeting in the gastrointestinal tract: new approaches.
  • W. Ritschel
  • Medicine
    Methods and findings in experimental and clinical pharmacology
  • 1991
TLDR
Targeting utilizes the anatomic, histologic, physiologic and biochemical features of various segments within the alimentary canal, paired with the design of special drug delivery systems or devices, and the use of special vehicle substances, such as polymers, bioadhesives, sorption promoters, or chemical modification of the active moiety.
Structure of mucosa in continent ileal reservoirs 15 to 19 years after construction.
Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man
TLDR
The results of this study are important for the appropriate dose translation of candidate therapeutic compounds in drug development from mouse to humans.
Analysis of length and surface area of each segment of the large intestine according to age, sex and physique
TLDR
Length, diameter and surface area of each of 6 segments of the large intestine were determined and calculated in 920 Japanese patients who underwent barium enema, with various sex differences in size.
GROWTH OF CRYPTS AND GLANDS OF THE HUMAN STOMACH
TLDR
The present paper is a report of a quantitative study of the growth in number of the gastric crypts and glands in later fetal life, infancy, childhood and adolescence, and to this have been added data on the number of these structures in maturity.
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
  • T. Kararli
  • Biology
    Biopharmaceutics & drug disposition
  • 1995
In addition to metabolic differences, the anatomical, physiological, and biochemical differences in the gastrointestinal (G.I.) tract of the human and common laboratory animals can cause significant…
...
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