Surface area of the digestive tract – revisited
@article{Helander2014SurfaceAO, title={Surface area of the digestive tract – revisited}, author={Herbert F. Helander and Lars F{\"a}ndriks}, journal={Scandinavian Journal of Gastroenterology}, year={2014}, volume={49}, pages={681 - 689} }
BACKGROUND
According to textbooks, the human gut mucosa measures 260-300 m(2), that is, in the order of a tennis court. [] Key MethodRESULTS
Literature review of intubation or radiological methods indicates an oroanal length of ∼5 m, two-third of which refers to the small intestine. However, there is a considerable variation between individuals. The inner diameter of the small intestine averages 2.5 cm and that of the large intestine averages 4.8 cm. The mucosa of the small intestine is enlarged ∼1.6 times…
520 Citations
Recent Studies on Digestive System Anatomy
- Computer Science
- 2018
The mean total mucosal surface of the human digestive tract averages ~32 m2, of which about 2 m2 corresponds to that of the large intestine [1]. The latter is built of a single layer of epithelial…
A slippery slope: On the origin, role and physiology of mucus☆
- BiologyAdvanced drug delivery reviews
- 2018
Turning the Lungs Inside Out: The Intersecting Microbiomes of the Lungs and the Built Environment
- BiologyAmerican journal of respiratory and critical care medicine
- 2020
The authors discovered that the lung microbiome in patients with BADE is distinct from that of matched BADEfree subjects, more closely resembling microbial communities detected in on-site metalworking fluid.
Development and Anatomy of the Enteroendocrine System in Humans.
- BiologyEndocrine development
- 2017
The anatomical characteristics, development, differentiation and maturation of EECs are described, and their important biological potential illustrated as part of the gut interacting sensory system.
Gastrointestinal mucus in dog: physiological characteristics, composition, and structural properties
- BiologyEuropean Journal of Pharmaceutics and Biopharmaceutics
- 2022
Quantitative whole-tissue 3D imaging reveals bacteria in close association with mouse jejunum mucosa
- Medicine, BiologybioRxiv
- 2022
The results suggest that dense bacterial colonization of jejunum mucosa is possible in the presence of multiple perturbations and that villus loss may be one possible consequence to such colonization.
Topography and microstructural organization of lymphoid formations associated with pig intestinal mucosa
- MedicineTheoretical and Applied Veterinary Medicine
- 2019
The patterns of lymphoid tissue formation during postnatal ontogeny can be useful in developing optimal vaccination time for piglets, drawing up treatment regimens and methods for the prevention of gastrointestinal diseases.
Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
- Biology, MedicineInternational journal of molecular sciences
- 2022
There was no additional increase in mannitol permeability induced by luminal ethanol or SDS in the chemotherapy-treated rats compared to controls, which may be related to the relatively high basal permeability ofMannitol compared to other common low-permeability probes.
Ultrastructural intestinal mucosa change after prolonged inhibition of gastric acid secretion by omeprazole in male rats
- Medicine, BiologyAnatomical Science International
- 2020
Omeprazole is a potent inhibitor of gastric acid secretion. It was reported that omeprazole induced dramatic gastric mucosa morphologic changes from the resting state to the stimulated state.…
References
SHOWING 1-10 OF 42 REFERENCES
Intestinal Absorptive Surface in Mammals of Different Sizes
- BiologyAdvances in Anatomy Embryology and Cell Biology
- 1997
A new method is described to measure the intestines of animals ranging in size from the harvest mouse to the horse, which may be applicable to other hollow or tube-like organs, and has two levels: obtaining the basal surface area of the entire intestine and accounting for any increase in the mucosal surface area that is due to microscopically visible folds, villi, or other such structures.
The oral mucosal surface and blood vessels
- MedicineHead & Face Medicine
- 2013
The total size of the oral mucosa was determined to show that the dorsal side of the tongue comprises a large proportion of the total oral mucosal surface and plays an important role in the oral resorption of drugs.
[Quantification of the three-dimensional structure of jejunal mucosa in healthy subjects and patients with coeliac disease (author's transl)].
- MedicineDeutsche medizinische Wochenschrift
- 1976
Mucosal transformation in coeliac disease was associated with a decrease in villi and crypts per mm2 intestine as well as in mucosal surface and an increase in crypt depth and number of mitotic figures per crypt.
Parenteral versus enteral nutrition: morphological changes in human adult intestinal mucosa.
- MedicineJournal of submicroscopic cytology and pathology
- 1996
Investigation of the effect of parenteral nutrition on the intestinal mucosa of human adults found that the thickness of the jejunal mucosa decreased already in enterally nourished patients with chronic pancreatitis, but was enhanced after total parenTERal nutrition.
Targeting in the gastrointestinal tract: new approaches.
- MedicineMethods and findings in experimental and clinical pharmacology
- 1991
Targeting utilizes the anatomic, histologic, physiologic and biochemical features of various segments within the alimentary canal, paired with the design of special drug delivery systems or devices, and the use of special vehicle substances, such as polymers, bioadhesives, sorption promoters, or chemical modification of the active moiety.
Structure of mucosa in continent ileal reservoirs 15 to 19 years after construction.
- MedicineHuman pathology
- 1990
Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man
- Medicine, BiologyLaboratory animals
- 2010
The results of this study are important for the appropriate dose translation of candidate therapeutic compounds in drug development from mouse to humans.
Analysis of length and surface area of each segment of the large intestine according to age, sex and physique
- MedicineSurgical and Radiologic Anatomy
- 2005
Length, diameter and surface area of each of 6 segments of the large intestine were determined and calculated in 920 Japanese patients who underwent barium enema, with various sex differences in size.
GROWTH OF CRYPTS AND GLANDS OF THE HUMAN STOMACH
- Medicine
- 1925
The present paper is a report of a quantitative study of the growth in number of the gastric crypts and glands in later fetal life, infancy, childhood and adolescence, and to this have been added data on the number of these structures in maturity.
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
- BiologyBiopharmaceutics & drug disposition
- 1995
In addition to metabolic differences, the anatomical, physiological, and biochemical differences in the gastrointestinal (G.I.) tract of the human and common laboratory animals can cause significant…