Surface and inside volumes in globular proteins

  title={Surface and inside volumes in globular proteins},
  author={Jo{\"e}l Janin},
  • J. Janin
  • Published 1979
  • Chemistry, Medicine
  • Nature
MEASUREMENTS of the surface area accessible to solvent provide a convenient definition of the surface and the inside volumes in proteins of known X-ray structure. The study of the accessibility to solvent of amino acid residues in several proteins1–3 has confirmed the early observation that polar residues are found mostly on the surface and non-polar residues mostly inside globular protein structures. But the accessibility shows systematic variations with the molecular weight, because of the… Expand

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