Surface and cytoplasmic immunoglobulin expression in B-cell chronic lymphocytic leukemia (CLL).

@article{Lewis2005SurfaceAC,
  title={Surface and cytoplasmic immunoglobulin expression in B-cell chronic lymphocytic leukemia (CLL).},
  author={Robert E Lewis and Julius M. Cruse and Samuel R Pierce and John Ym Lam and Yousef Tadros},
  journal={Experimental and molecular pathology},
  year={2005},
  volume={79 2},
  pages={146-50}
}
Flow cytometric analysis of abnormal lymphocyte populations in chronic lymphocytic leukemia (CLL) has been widely reported to show weak expression of surface immunoglobulin (sIg). The international scoring system to help discriminate between CLL and other B-cell lymphoproliferative disorders lists this as the first of 5 criteria worth 1 point each. In the present study, 30 cases of CLL were studied for surface and cytoplasmic Ig expression. 23 of these 30 (76.7%) cases were positive for sIg. Of… CONTINUE READING