Surface activity of angiotensin

Abstract

Studies of the renin-angiotensin-aldosterone system are dictated by the rapidly growing incidence of cardiovascular diseases. This system plays a key role in metabolic reactions in various forms of cardiac insufficiency and regulates the general and renal circulation, water-electrolyte balance, arterial pressure, aldosterone level, etc. [7]. The most active component of this system is angiotensin-2; some authors [2,6,7] believe that, in binding with a receptor, it stimulates inositol triphosphate production, this being followed by a rise of the intracellular ionized calcium level and activation of proteinkinase C. The pr imary mechanisms of angiotensin-2 binding with membranes are unknown, but oxytocin and substance P, which are similar to this peptide in structure, were recently discovered to bind with the lipid matrix of the membranes [35]; this prompted us to investigate the surface-active properties of angiotensin-2, one of the factors of peptide-membrane interaction.

DOI: 10.1007/BF00786163

2 Figures and Tables

Cite this paper

@article{Rybalchenko2004SurfaceAO, title={Surface activity of angiotensin}, author={V. K. Rybal'chenko and Vadim S. Sedov and A. M. Shamonina and I. L. Reshetnyak}, journal={Bulletin of Experimental Biology and Medicine}, year={2004}, volume={116}, pages={826-827} }