Progress in Science and Pechnology
- G. Yu. Grigoryan
- Human and Animal Physiology Series [in Russian],
Studies of the renin-angiotensin-aldosterone system are dictated by the rapidly growing incidence of cardiovascular diseases. This system plays a key role in metabolic reactions in various forms of cardiac insufficiency and regulates the general and renal circulation, water-electrolyte balance, arterial pressure, aldosterone level, etc. . The most active component of this system is angiotensin-2; some authors [2,6,7] believe that, in binding with a receptor, it stimulates inositol triphosphate production, this being followed by a rise of the intracellular ionized calcium level and activation of proteinkinase C. The pr imary mechanisms of angiotensin-2 binding with membranes are unknown, but oxytocin and substance P, which are similar to this peptide in structure, were recently discovered to bind with the lipid matrix of the membranes ; this prompted us to investigate the surface-active properties of angiotensin-2, one of the factors of peptide-membrane interaction.