Surface-active phospholipid as the lubricating component of lubricin.

@article{Schwarz1998SurfaceactivePA,
  title={Surface-active phospholipid as the lubricating component of lubricin.},
  author={Ivo Schwarz and Brian A. Hills},
  journal={British journal of rheumatology},
  year={1998},
  volume={37 1},
  pages={21-6}
}
To resolve the apparent conflict between a lubricating glycoprotein, 'lubricin', as the active ingredient in synovial fluid (SF) and surface-active phospholipid (SAPL) present in SF (and adsorbed to articular cartilage) as the boundary lubricant reducing friction to such low physiological levels, lubricin was isolated from bovine SF following the original procedure of Swann et al. (Arthritis Rheum 1981;24:22-30). Analysis of the lipid extract by thin-layer chromatography and phosphorus… CONTINUE READING