Surface active drugs significantly alter the drug output rate from medical nebulizers.

Abstract

BACKGROUND Surface tension of aqueous solutions has a great impact on the resulting size of the produced aerosol droplets. Nevertheless, little attention has been drawn so far to the drug output of surface active substances during nebulization. METHODS Six nebulizers with three different nebulization mechanisms were operated on the breath simulator and… (More)
DOI: 10.1016/j.ijpharm.2009.10.012

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