Surface Modifying Additives Reduce Thrombogenicity: An In Vitro and Clinical Evaluation

@inproceedings{Spijker1997SurfaceMA,
  title={Surface Modifying Additives Reduce Thrombogenicity: An In Vitro and Clinical Evaluation},
  author={H. vant Spijker and J. Bierens de Haan and Reindert Graaff and Piet Willem Boonstra and Wim van Oeveren},
  year={1997}
}
To improve the biocompatibility of biomaterials a new surface treatment has been described based on the addition of polysiloxane containing copolymers to the base polymer resin (surface modifying additives). In an in vitro and a clinical study, we compared the thrombogenicity of polyvinyl chloride (PVC) to PVC with these surface modifying additives (SMA). In the in vitro study, adsorption of thrombin and fibrinogen, binding of platelets and platelet release were measured on the tubing and were… CONTINUE READING

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