Surface-Enhanced Raman Spectroscopy as a Tool for Probing Specific Biochemical Components in Bacteria

@article{Zeiri2004SurfaceEnhancedRS,
  title={Surface-Enhanced Raman Spectroscopy as a Tool for Probing Specific Biochemical Components in Bacteria},
  author={Leila Zeiri and Burt V. Bronk and Yossef Shabtai and Jerry Eichler and Schlomo Efrima},
  journal={Applied Spectroscopy},
  year={2004},
  volume={58},
  pages={33 - 40}
}
Treatment of bacteria with silver yields intense and highly specific surface-enhanced Raman spectroscopy (SERS) spectra from various cellular chemical components located in the vicinity of the silver colloids. In particular, we demonstrate an extreme sensitivity to flavin components associated with the cell envelope and to their state of oxidation. Different spectra, possibly associated with DNA, carboxylates, and perhaps phosphates, are obtained from the soluble interior fraction of the cell. 
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