Surface Crystallization of Indomethacin Below T g

@article{Wu2006SurfaceCO,
  title={Surface Crystallization of Indomethacin Below T g},
  author={Tian Wu and Lian Yu},
  journal={Pharmaceutical Research},
  year={2006},
  volume={23},
  pages={2350-2355}
}
To study the surface crystallization of indomethacin (IMC) below T g and its effects on the kinetics of overall crystallization. Crystal growth rates in liquid layers formed between microscope cover glasses were measured with the top cover glass in place and removed. Polymorphs were identified by powder X-ray diffraction, Raman microscopy, and melting-point determination by hot-stage microscopy. Surface crystals were identified by scratching the sample surface, by cutting the sample to expose… CONTINUE READING

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