Surface CD4 density remains constant on lymphocytes of HIV-infected patients in the progression of disease.

@article{Poncelet1991SurfaceCD,
  title={Surface CD4 density remains constant on lymphocytes of HIV-infected patients in the progression of disease.},
  author={Philippe Poncelet and G Poinas and Pierre Corbeau and Christian A Devaux and Nicole Tubiana and N Muloko and Catherine Tamalet and Jean Claude Chermann and François M. Kourilsky and Jos{\'e} Sampol},
  journal={Research in immunology},
  year={1991},
  volume={142 4},
  pages={291-8}
}
In an attempt to question the influence of circulating virus, soluble gp120 or CD4 self-reacting antibodies upon results of CD4+ T-cell immunophenotyping in AIDS patients, five anti-CD4 mAb defining several epitopes of the V1 and V2 domains of the CD4 molecule were used to analyse the epitopic density of CD4 on lymphocytes of seropositive patients taken at stages II, III and IV of HIV infection, according to the Centers for Disease Control (CDC, Atlanta) classification. Our results demonstrate… CONTINUE READING