• DOI:10.1007/978-3-540-85988-8_120
• Corpus ID: 593761

Surface-Based Vector Analysis Using Heat Equation Interpolation: A New Approach to Quantify Local Hippocampal Volume Changes

@article{Kim2008SurfaceBasedVA,
  title={Surface-Based Vector Analysis Using Heat Equation Interpolation: A New Approach to Quantify Local Hippocampal Volume Changes},
  author={Hosung Kim and Pierre Besson and Olivier Colliot and Andrea Bernasconi and Neda Bernasconi},
  journal={Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention},
  year={2008},
  volume={11 Pt 1},
  pages={
          1008-15
        }
}

• Hosung Kim, P. Besson, +2 authors N. Bernasconi
• Published 6 September 2008
• Biology
• Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Analysis of surface-based displacement vectors using spherical harmonic description (SPHARM) localizes shape changes accurately. However, it does not allow differentiating volume variations from shifting and/or bending. We propose a new approach to quantify local volume changes by computing the surface-based Jacobian determinant. This measurement is computed on the displacement vector fields estimated by a heat equation interpolation on the displacement vectors produced by SPHARM. Data simulation showed that the surface-based Jacobian determinant enables accurate quantification of local volume changes without interference of shifting/bending. In patients with temporal lobe epilepsy and left hippocampal atrophy, SPHARM detected widespread inward deformation related to atrophy in the hippocampal head and body, and showed areas of mirrored inward/outward deformations mostly at the level of the hippocampal tail. In these areas, the surface-based Jacobian determinant showed atrophy. Our method facilitates the interpretation of SPHARM because it allows decomposing volume changes and shifting/bending. Furthermore, it provides a better delineation of the extent of hippocampal atrophy.