Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target

@inproceedings{Hsiao2013SurfaceP,
  title={Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target},
  author={Kuan-Chung Hsiao and Nianhao Shih and Hsun-Lang Fang and Tze-Sing Huang and Ching-Chuan Kuo and P G Chu and Yi-Mei Hung and Shao-Wen Chou and Yi-yuan Yang and G C Chang and Ko-Jiunn Liu},
  booktitle={PloS one},
  year={2013}
}
In previous research, we found α-enolase to be inversely correlated with progression-free and overall survival in lung cancer patients and detected α-enolase on the surface of lung cancer cells. Based on these findings, we hypothesized that surface α-enolase has a significant role in cancer metastasis and tested this hypothesis in the current study. We found that α-enolase was co-immunoprecipitated with urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor, and… CONTINUE READING
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