Surface‐targeted lysosomal membrane glycoprotein‐1 (Lamp‐1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi

@article{Kima2000SurfacetargetedLM,
  title={Surface‐targeted lysosomal membrane glycoprotein‐1 (Lamp‐1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi},
  author={Peter E Kima and Barbara A. Burleigh and Norma W. Andrews},
  journal={Cellular Microbiology},
  year={2000},
  volume={2}
}
To gain entry into non‐phagocytic cells, Trypanosoma cruzi trypomastigotes recruit lysosomes to the host cell surface. Lysosome fusion at the site of parasite entry leads to the formation of a parasitophorous vacuole with lysosomal properties. Here, we show that increased expression of the lysosomal membrane glycoprotein Lamp‐1 at the cell surface renders CHO cells more susceptible to trypomastigote invasion in a microtubule‐dependent fashion. Mutation of critical residues in the lysosome… 
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