Suramin protects from cisplatin-induced acute kidney injury.

@article{Dupre2016SuraminPF,
  title={Suramin protects from cisplatin-induced acute kidney injury.},
  author={Tess V. Dupre and Mark A. Doll and Parag P. Shah and Cierra Nichole Sharp and Alex Kiefer and Michael Thomas Scherzer and Kumar Jha Saurabh and Doug Saforo and Deanna Leigh Siow and Lavona K. Casson and Gavin E. Arteel and Alfred Bennett Jenson and Judit K. Megyesi and Rick G Schnellmann and Levi J. Beverly and Leah J. Siskind},
  journal={American journal of physiology. Renal physiology},
  year={2016},
  volume={310 3},
  pages={
          F248-58
        }
}
Cisplatin, a commonly used cancer chemotherapeutic, has a dose-limiting side effect of nephrotoxicity. Approximately 30% of patients administered cisplatin suffer from kidney injury, and there are limited treatment options for the treatment of cisplatin-induced kidney injury. Suramin, which is Federal Drug Administration-approved for the treatment of trypanosomiasis, improves kidney function after various forms of kidney injury in rodent models. We hypothesized that suramin would attenuate… CONTINUE READING

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 58 REFERENCES

IRE1: ER stress sensor and cell fate executor.

  • Trends in cell biology
  • 2013
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Acute renal failure.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.

  • Journal of the American Society of Nephrology : JASN
  • 2003
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

  • BioMed research international
  • 2014
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Acute kidney injury

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Recovery from glycerol-induced acute kidney injury is accelerated by suramin.

  • The Journal of pharmacology and experimental therapeutics
  • 2012
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL