Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects.

@article{MargollesClark2009SuraminIT,
  title={Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects.},
  author={Emilio Margolles-Clark and Maria Caroline Jacques-Silva and Lakshmi Ganesan and Oliver Umland and Norma Sue Kenyon and Camillo Ricordi and P. -O. Berggren and Peter Buchwald},
  journal={Biochemical pharmacology},
  year={2009},
  volume={77 7},
  pages={
          1236-45
        }
}
Suramin is a symmetric polysulfonated naphthylamine-benzamide urea derivative approved for the treatment of trypanosomiasis and onchocerciasis and a known P2 (ATP/UTP purine receptor) antagonist. Here, we report its ability to inhibit the important CD40-CD154 costi-mulatory interaction required for T cell activation and the development of an effective immune response. In vitro, it inhibited the binding of both human and murine CD154 (CD40L) to their receptor (CD40) even in the presence of… CONTINUE READING
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