Suramin inhibits death receptor–induced apoptosis in vitro and fulminant apoptotic liver damage in mice

@article{Eichhorst2004SuraminID,
  title={Suramin inhibits death receptor–induced apoptosis in vitro and fulminant apoptotic liver damage in mice},
  author={S{\"o}ren T. Eichhorst and Andreas Krueger and Susanne M{\"u}erk{\"o}ster and Stefanie C. Fas and Alexander Golks and Uwe Gruetzner and Louise Schubert and Christine Opelz and Manfred Bilzer and Alexander L Gerbes and Peter Heinrich Krammer},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={602-609}
}
Suramin is a polysulfonated derivative of urea and has been widely used both to treat infections and as a chemotherapeutic drug. Suramin has been shown to inhibit growth factor signaling pathways; however, its effect on apoptosis is unknown. Here we show that suramin inhibits apoptosis induced through death receptors in hepatoma and lymphoma cells. It also inhibits the proapoptotic effect of chemotherapeutic drugs. The antiapoptotic mechanism is specific to cell type and is caused by reduced… CONTINUE READING
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Structure - activity relationships of suramin and pyridoxal - 5 ′ - phosphate derivatives as P 2 receptor antagonists

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