Sural nerve pathology in ALS patients: a single-centre experience

  title={Sural nerve pathology in ALS patients: a single-centre experience},
  author={Marco Luigetti and Amelia Conte and Alessandra Del Grande and Giulia Bisogni and Angela Romano and Mario Sabatelli},
  journal={Neurological Sciences},
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of upper and lower motor neurons. Sensory involvement is thought not to be a feature of ALS. We reviewed 17 cases of sural nerve biopsies performed in a large cohort of ALS patients referred to our centre over a 23-year period. More than two-third of biopsies revealed a variable degree of axonal loss. In one case, pathological findings suggested the concomitant presence of an inherited neuropathy, subsequently confirmed… CONTINUE READING