Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.

@article{Goodchild2004SupraspinalAS,
  title={Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.},
  author={Colin S. Goodchild and Ray Nadeson and Eddie Cohen},
  journal={European journal of anaesthesiology},
  year={2004},
  volume={21 3},
  pages={179-85}
}
BACKGROUND AND OBJECTIVE The clinical practice of spinal morphine administration for pain relief is based on observations in animals that opioid receptors exist in the spinal cord and intrathecal injections of opioids in those species (mostly rats) lead to antinociceptive effects. Clinicians are well aware that administration of spinal opioids is associated with side-effects, such as nausea and respiratory depression, that indicate supraspinal spread of the drug administered. Those observations… CONTINUE READING

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