Supraphysiologic concentrations of cerulein induce apoptosis in the rat pancreatic acinar cell line AR4-2J.

@article{Sata1999SupraphysiologicCO,
  title={Supraphysiologic concentrations of cerulein induce apoptosis in the rat pancreatic acinar cell line AR4-2J.},
  author={Naohiro Sata and Hanne Klonowski-Stumpe and Bing Han and Reinhard L{\"u}then and Dieter H{\"a}ussinger and Claus Niederau},
  journal={Pancreas},
  year={1999},
  volume={19 1},
  pages={76-82}
}
Little is known as yet about the role of apoptosis in pancreatic damage. This study evaluated the effects of supraphysiologic concentrations of the cholecystokinin (CCK) analog, cerulein, which causes cell damage in vitro and acute pancreatitis in vivo, on cell proliferation and DNA fragmentation in the rat pancreatic acinar cell line AR4-2J. Cerulein inhibited the cell proliferation of AR4-2J time- and dose-dependently to approximately 60% of the control level at 10(-6) M after 72 h. DNA… CONTINUE READING