Supramolecular organization of the mammalian translation system.

  title={Supramolecular organization of the mammalian translation system.},
  author={Boris Negrutskii and Romualdas Stapulionis and Murray P. Deutscher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 3},
Although evidence suggests that the protein synthetic machinery is organized within cells, this point has been difficult to prove because any organization that might exist is lost upon preparation of the cell-free systems usually used to study translation in vitro. To examine this process under conditions more representative of the intact cell, we have developed an active protein-synthesizing system using Chinese hamster ovary (CHO) cells permeabilized with the plant glycoside saponin. This… CONTINUE READING
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