Supramolecular devices to improve the treatment of brain diseases.

  title={Supramolecular devices to improve the treatment of brain diseases.},
  author={Donatella Paolino and Donato Cosco and Roberto Molinaro and Christian Celia and Massimo Fresta},
  journal={Drug discovery today},
  volume={16 7-8},
The blood-brain barrier (BBB) hinders the accumulation of active compounds in the central nervous system, thus decreasing their therapeutic effectiveness. To overcome this obstacle, interesting supramolecular nanodevices are herein considered. These systems have many advantages over the conventional formulations, such as having structures made up of biocompatible and biodegradable materials, the possibility of bypassing the BBB in a non-invasive manner (without structural modifications) and the… CONTINUE READING
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