Supramolecular GAG-like Self-Assembled Glycopeptide Nanofibers Induce Chondrogenesis and Cartilage Regeneration.

@article{Yaylaci2016SupramolecularGS,
  title={Supramolecular GAG-like Self-Assembled Glycopeptide Nanofibers Induce Chondrogenesis and Cartilage Regeneration.},
  author={Seher Ustun Yaylaci and Melis Sardan Ekiz and Elif Arslan and Nuray Can and Erden Kilic and Huseyin Ozkan and Ilghar Orujalipoor and Semra Ide and Ayse B Tekinay and Mustafa O Guler},
  journal={Biomacromolecules},
  year={2016},
  volume={17 2},
  pages={679-89}
}
Glycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, and migration and tissue homeostasis. Here, we demonstrate supramolecular GAG-like glycopeptide nanofibers mimicking bioactive functions of natural hyaluronic acid molecules. Self-assembly of the glycopeptide amphiphile molecules enable organization of glucose residues in close proximity on a nanoscale structure forming a supramolecular GAG-like system… CONTINUE READING
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