Supramaximal CCK-58 does not induce pancreatitis in the rat: role of pancreatic water secretion.

@article{Yamamoto2007SupramaximalCD,
  title={Supramaximal CCK-58 does not induce pancreatitis in the rat: role of pancreatic water secretion.},
  author={Mitsuyoshi Yamamoto and Joseph R. Reeve and Gary M. Green},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={292 4},
  pages={G964-74}
}
In contrast to supramaximal CCK-8 or caerulein, acute or prolonged supraphysiological levels of endogenous CCK-58 do not cause pancreatitis. Compared with CCK-8, CCK-58 is a much stronger stimulant of pancreatic chloride and water secretion, equivalent to maximally effective secretin, but with a chloride-to-bicarbonate ratio characteristic of acinar fluid… CONTINUE READING