Supralinear Ca 2 1 Signaling by Cooperative and Mobile Ca 2 1 Buffering in Purkinje Neurons

@inproceedings{Maeda1999SupralinearC2,
  title={Supralinear Ca 2 1 Signaling by Cooperative and Mobile Ca 2 1 Buffering in Purkinje Neurons},
  author={Hitoshi Maeda and Graham C. R. Ellis-Davies and Koichi Ito and Yasushi Miyashita and Haruo Kasai},
  year={1999}
}
that mice deficient in calbindin-D 28K exhibit cerebellar ataxia (Airaksinen et al., 1997a) and impaired spatial Hongo, Bunkyo-ku Tokyo 113 learning (Molinari et al., 1996). However, the properties of high-affinity Ca 2ϩ buffering in vivo and its specific Japan † Department of Pharmacology and Physiology consequences for neuronal Ca 2ϩ signaling have not been elucidated. We have therefore now investigated Ca 2ϩ buffering in Purkinje cells with the use of a low-affinity (‫01ف‬ ␮M) Ca 2… CONTINUE READING
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