Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization

@article{Choi2014SuprafenacineAI,
  title={Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization},
  author={Bo-Hwa Choi and S. Chattopadhaya and Le Nguyen Thanh and L. Feng and Q. T. Nguyen and C. Lim and A. Harikishore and R. Nanga and N. Bharatham and Yan Zhao and X. Liu and H. Yoon},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Microtubules are a highly validated target in cancer therapy. [...] Key Result SRF, identified by in silico screening of annotated chemical libraries, was shown to bind microtubules at the colchicine-binding site and inhibit polymerization. This led to G2/M cell cycle arrest and cell death via a mitochondria-mediated apoptotic pathway. Cell death was preceded by loss of mitochondrial membrane potential, JNK-mediated phosphorylation of Bcl-2 and Bad, and activation of caspase-3.Expand
Cytotoxic activity of a synthetic deoxypodophyllotoxin derivative with an opened D-ring
Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis
A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels

References

SHOWING 1-10 OF 56 REFERENCES
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
Bcl2 is the guardian of microtubule integrity.
The role of MAPK pathways in the action of chemotherapeutic drugs.
...
1
2
3
4
5
...