Suprabasal spongiosis in acute eczematous dermatitis: cFLIP maintains resistance of basal keratinocytes to T-cell-mediated apoptosis.

@article{Armbruster2009SuprabasalSI,
  title={Suprabasal spongiosis in acute eczematous dermatitis: cFLIP maintains resistance of basal keratinocytes to T-cell-mediated apoptosis.},
  author={Nicole Armbruster and Axel Trautmann and E V Br{\"o}cker and Martin Leverkus and Andreas Kerstan},
  journal={The Journal of investigative dermatology},
  year={2009},
  volume={129 7},
  pages={1696-702}
}
In acute eczematous dermatitis, keratinocyte (KC) apoptosis caused by dermis-infiltrating, activated T cells plays a crucial pathogenetic role in the development of spongiosis, the histopathological hallmark of acute eczema. Remarkably, T-cell-mediated apoptosis of single KC, as well as spongiosis, is located predominantly in suprabasal epidermal layers… CONTINUE READING