Supraadditive formation of micronuclei in preimplantation mouse embryos in vitro after combined treatment with X-rays and caffeine.


The influence of caffeine (0.1 or 2 mM), X-rays (0.24 Gy [= 25 R] or 0.94 Gy [= 100 R]), or of a combination of both on the formation of micronuclei in early stages of preimplantation mouse embryos in vitro was studied. X-rays as well as caffeine induced micronuclei. The dose-effect curve after irradiation was linear for the dose range measured (0-3.76 Gy… (More)


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