Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro.

@article{Charles2012SupraphysiologicalFA,
  title={Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro.},
  author={Michelle A. Charles and Ian T Johnson and Nigel Junior Belshaw},
  journal={Epigenetics},
  year={2012},
  volume={7 7},
  pages={689-94}
}
The micronutrients folate and selenium may modulate DNA methylation patterns by affecting intracellular levels of the methyl donor S-adenosylmethionine (SAM) and/or the product of methylation reactions S-adenosylhomocysteine (SAH). WI-38 fibroblasts and FHC colon epithelial cells were cultured in the presence of two forms of folate or four forms of selenium at physiologically-relevant doses, and their effects on LINE-1 methylation, gene-specific CpG island (CGI) methylation and intracellular… CONTINUE READING