Supra-domains: evolutionary units larger than single protein domains.

@article{Vogel2004SupradomainsEU,
  title={Supra-domains: evolutionary units larger than single protein domains.},
  author={Christine Vogel and Carlo Berzuini and Matthew Bashton and Julian Gough and Sarah A. Teichmann},
  journal={Journal of molecular biology},
  year={2004},
  volume={336 3},
  pages={
          809-23
        }
}
Domains are the evolutionary units that comprise proteins, and most proteins are built from more than one domain. Domains can be shuffled by recombination to create proteins with new arrangements of domains. Using structural domain assignments, we examined the combinations of domains in the proteins of 131 completely sequenced organisms. We found two-domain and three-domain combinations that recur in different protein contexts with different partner domains. The domains within these… CONTINUE READING
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