Supra-Additive Neuroprotection by Renexin, a Mixed Compound of Ginkgo Biloba Extract and Cilostazol, Against Apoptotic White Matter Changes in Rat after Chronic Cerebral Hypoperfusion

@article{Kwak2012SupraAdditiveNB,
  title={Supra-Additive Neuroprotection by Renexin, a Mixed Compound of Ginkgo Biloba Extract and Cilostazol, Against Apoptotic White Matter Changes in Rat after Chronic Cerebral Hypoperfusion},
  author={Pil Ae Kwak and S. C. Lim and Si-Ryung Han and Young-Min Shon and Y. Kim},
  journal={Journal of Clinical Neurology (Seoul, Korea)},
  year={2012},
  volume={8},
  pages={284 - 292}
}
  • Pil Ae Kwak, S. C. Lim, +2 authors Y. Kim
  • Published 2012
  • Medicine
  • Journal of Clinical Neurology (Seoul, Korea)
  • Background and Purpose White-matter (WM) lesions are known to potentiate cognitive impairment in poststroke patients. The present study was designed to assess whether Ginkgo biloba extract (GB) and cilostazol, which were evaluated alone and in a combination formula (Renexin), can attenuate the WM lesions and cognitive decline caused by chronic hypoperfusion in the rat. Methods Animals were divided into five treatment groups: cilostazol (25 mg/kg/day), GB (20 mg/kg/day), Renexin (25 mg/kg/day… CONTINUE READING
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