Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.

Abstract

Using high-throughput screening we identified small molecules that suppress superoxide and/or H2O2 production during reverse electron transport through mitochondrial respiratory complex I (site IQ) without affecting oxidative phosphorylation (suppressors of site IQ electron leak, "S1QELs"). S1QELs diminished endogenous oxidative damage in primary astrocytes… (More)
DOI: 10.1016/j.cmet.2016.08.012

7 Figures and Tables

Topics

Statistics

010020020172018
Citations per Year

139 Citations

Semantic Scholar estimates that this publication has 139 citations based on the available data.

See our FAQ for additional information.

  • Presentations referencing similar topics